A Prospective Study of Dry Eyes Disease among Patients Using Oral Hydroxychloroquine at Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India

Satya Sharma, Chetanya Prakash Gupta, Bharat Meharda, Daya Chand Gupta, Manish Choudhary

Abstract


 Background: Dry eye disease (DED) is a multifactorial disease of the interpalpebral ocular surface and tear film that leads to discomfort, fatigue, and disturbance in vision. In severe cases, DED can also lead to permanent visual impairment. Materials and Methods: It was a hospital-based prospective study, conducted at the Department of Ophthalmology, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India, along with the coordination of the Department of Dermatology, Orthopedics, and Pathology from January 2019 to June 2020. Results: The mean age of the patients was 44.0 ± 8.63 years ranging from 24 years to 65 years. Majority (56%) were 41–60 years. Male-to-female ratio was 1:1. The difference between the mean ocular surface disease index (OSDI) on day 1 and day 90 was found statistically significant. The mean Schirmer’s test value on day 1, 21.2 ± 5.1, day 45 16.3 ± 6.3, and day 90, 14.5 ± 6.6. Conclusions: In the present study, patients OSDI scores increase as time of follow-up increases.

Key words: Dry eye disease, Hydroxychloroquine, Ocular surface disease index, Schirmer tear test


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