Predictive Value of Proteinuria in Assessing Severity of Dengue Infection in Children

Vookanti Smruti, Gurram Sudharani, Palle Amarender Reddy, Seepana Rajesh

Abstract


 Background: Dengue fever has emerged as a major health problem globally with several complications occur which lead to increasing morbidity and mortality. It has, therefore, become important to establish accurate, easy to perform predictors of disease severity to enable timely management, and prevent associated complications. Such markers have not been well researched in pediatric population. This study was undertaken to establish early predictors of disease severity, urine protein-creatinine ratio (UPCR), and proteinuria in children with dengue. Objectives: The objectives of the study were to correlate UPCR with severity of illness in children diagnosed to have dengue infection. Materials and Methods: A hospital-based prospective observational study was carried out among 140 children admitted at Niloufer Hospital, a tertiary care teaching pediatric hospital attached to Osmania Medical College, Hyderabad, Telangana, during the study period of 2 years. SPSS 19.0 software was used to analyze the data. Results: Among the 140 children, 29 children were categorized as severe dengue, 34 as dengue with warning signs, and 77 as probable dengue. There were 11 deaths which counted for 0.07% of total study population. The mean UPCR and proteinuria showed peak during day 5 and day 6 of illness in all three groups of study population with statistical significance of P < 0.05. Conclusion: There was a positive correlation between UPCR and severity of dengue illness. The onset and the peak of proteinuria using UPCR have a significant association with subsequent development of severe dengue.

Key words: Dengue fever, dip stick, proteinuria, urine protein-creatinine ratio


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