CRP – A Marker of Severity of Dengue in a Non-Tropical Community

Ajaz Nabi Koul, Sajad Ahmad Bhat, Samiya Yusuf

Abstract


Objective: The study was undertaken to determine the value of CRP in the assessment of severity of dengue in a non-tropical population. Materials and Methods: Kashmir being a temperate region does not have indigenous dengue due to non-survival of vector so immunobiology and clinical profile differ from rest of the country. A prospective hospital-based study was done at a tertiary care hospital Sher-i-Kashmir Institute of Medical Sciences in the Department of Internal Medicine (Division of Infectious Disease). Patients above 18 years of age who were diagnosed dengue using NS1 antigen and IgM antibody as a dengue-specific diagnostic tool were taken for the study. The detailed clinical profile and laboratory parameters were recorded. CRP levels were measured and compared between severe and non-severe dengue groups. Results: It was a hospital-based prospective study done on 55 patients who were diagnosed with dengue infection and the mean age of patients was 35 ± 17 years. All the patients were divided into three groups; severe dengue, non-severe with warning signs, and non-severe without warning signs. Among these patients, 18.1% suffered from severe dengue, 52.7% had non-severe dengue without warning signs, and 29.09% had non-severe dengue with warning signs. The median CRP level was measured (90.2 vs. 6.0 mg/dl) which was seen significantly higher in patients with severe dengue infection as compared to non-severe dengue patients and p value was measured (≤0.0003) which was statistically significant. Conclusion: CRP level can be used as a biomarker in the assessment of severity of dengue and in predicting acute dengue infection, especially in non-tropical, non-indigenous dengue patients.

Key words: Non-tropical, Dengue, CRP


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